TRPM8 Channels and Dry Eye
نویسندگان
چکیده
منابع مشابه
A novel TRPM8 agonist relieves dry eye discomfort
BACKGROUND Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to cooling) but not TRPV1 or TRPA1 (linked to nociception) and tested C3 in subjec...
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Polyphosphate (polyP) is an inorganic polymer built of tens to hundreds of phosphates, linked by high-energy phosphoanhydride bonds. PolyP forms complexes and modulates activities of many proteins including ion channels. Here we investigated the role of polyP in the function of the transient receptor potential melastatin 8 (TRPM8) channel. Using whole-cell patch-clamp and fluorescent calcium me...
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Expressed sequence tag (EST), proteomic, and antibody capture assays are revealing a level of tear film protein complexity far greater than previously appreciated. A systems biology approach will be needed to fully appreciate function as tear protein doses fluctuate in time through different conditions. Although consensus is growing on what fully constitutes the human tear proteome, questions r...
متن کاملHormones and Dry Eye Disease
Dry eye disease (DED) is a very prevalent eye disorder, affecting 40 million people in the United States alone. The primary cause of DED is meibomian gland dysfunction (MGD) [1], which by itself is a disease entity. The meibomian gland is a large sebaceous gland located in the tarsal plate of the eye lids. It functions to synthesize and secrete lipids onto the ocular surface. These lipids make ...
متن کاملDry eye, blinking, and blepharospasm.
The primary purpose of the eyelids is to ensure corneal integrity. An important component of this protective function is maintaining the corneal tear film. Blink characteristics can determine tear film stability. Increasing blink amplitude thickens the lipid layer that overlies the aqueous layer of the tear film. This thickening reduces evaporation of the aqueous layer. Because each blink refor...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2018
ISSN: 1424-8247
DOI: 10.3390/ph11040125